Mechanochemical Grignard Reactions with Gaseous CO <sub>2</sub> and Sodium Methyl Carbonate**
Victoria S. Pfennig, Romina C. Villella, Julia Nikodemus, Carsten Bolm
Abstract
Abstract A one‐pot, three‐step protocol for the preparation of Grignard reagents from organobromides in a ball mill and their subsequent reactions with gaseous carbon dioxide (CO 2 ) or sodium methyl carbonate providing aryl and alkyl carboxylic acids in up to 82 % yield is reported. Noteworthy are the short reaction times and the significantly reduced solvent amounts [2.0 equiv. for liquid assisted grinding (LAG) conditions]. Unexpectedly, aryl bromides with methoxy substituents lead to symmetric ketones as major products.
Topics & Concepts
ChemistryArylReagentAlkylCarbonateSolventYield (engineering)Carbon dioxideSodium carbonateDiethyl carbonateBall millOrganic chemistrySodiumInorganic chemistryMedicinal chemistryChemical engineeringMaterials scienceEthylene carbonateElectrodeEngineeringElectrolyteMetallurgyPhysical chemistryCarbon dioxide utilization in catalysisCoordination Chemistry and OrganometallicsCatalytic Cross-Coupling Reactions