Chronic intermittent hypoxia facilitates the development of angiotensin II-induced abdominal aortic aneurysm in male mice
Neekun Sharma, Abdelnaby Khalyfa, Dunpeng Cai, Mariana Morales‐Quinones, Rogério N. Soares, Yusuke Higashi, Shi‐You Chen, David Gozal, Jaume Padilla, Camila Manrique‐Acevedo, Bysani Chandrasekar, Luis A. Martinez‐Lemus
Abstract
IH facilitates Ang II-induced abdominal aortic diameter expansion and AAA development in C57BL/6J male mice. IH upregulates the expression of specific MMPs such as MMP8, MMP12, and ADAM17. IH directly suppresses RECK expression and increases MMPs activity in SMCs. Human AAA tissues exhibit a downregulation of RECK and an upregulation of ADAM17 and MMPs.
Topics & Concepts
Abdominal aortic aneurysmAngiotensin IIMatrix metalloproteinaseMedicineElastinHypoxia (environmental)MetalloproteinaseMMP9Internal medicineAortaEndocrinologyAortic aneurysmPathologyDownregulation and upregulationReceptorAneurysmBiologyChemistrySurgeryOrganic chemistryBiochemistryOxygenGeneAortic aneurysm repair treatmentsAortic Disease and Treatment ApproachesVascular anomalies and interventions