Diastereo‐ and Enantioselective 1,4‐Difunctionalization of Borylenynes by Catalytic Conjunctive Cross‐Coupling
Chunyin M. Law, Elton Kativhu, Johnny Wang, James P. Morken
Abstract
Enantioselective conjunctive cross-coupling of enyne-derived boronate complexes occurs with 1,4 addition of the electrophile and migrating group across the π system. This reaction pathway furnishes α-boryl allenes as the reaction product. In the presence of a chiral catalyst, both the central and axial chirality of the product can be controlled during product formation.
Topics & Concepts
Enantioselective synthesisCatalysisCoupling (piping)ChemistryOrganic chemistryMaterials scienceMetallurgyOrganoboron and organosilicon chemistryCatalytic C–H Functionalization MethodsRadical Photochemical Reactions