Novel treatment for refractory rheumatoid arthritis with total glucosides of paeony and nobiletin codelivered in a self-nanoemulsifying drug delivery system
Biao Qu, Xiaolin Wang, De-Chong Zheng, Chu-Tian Mai, Zhongqiu Liu, Hua Zhou, Ying Xie
Topics & Concepts
BioavailabilityPharmacologyRheumatoid arthritisMethotrexatePaeoniflorinMedicineArthritisPharmacokineticsDrugP-glycoproteinDrug deliveryInternal medicineChemistryMultiple drug resistanceBiochemistryOrganic chemistryAntibioticsHigh-performance liquid chromatographyChromatographyNatural product bioactivities and synthesisNatural Compounds in Disease TreatmentMedicinal Plant Pharmacodynamics Research