Alginate/pectin dressing with niosomal mangosteen extract for enhanced wound healing: evaluating skin irritation by structure-activity relationship
Philaslak Pooprommin, Chawan Manaspon, Anupma Dwivedi, Anisha Mazumder, Surat Sangkaew, Smith Wanmasae, Jitbanjong Tangpong, Tassanee Ongtanasup, Komgrit Eawsakul
Abstract
crosslinking were 867 wt% and 1,025 wt%, respectively, after 30 min. These results suggested that a medium dose (15 mg) of niosomal ME incorporated in a hydrogel film provided better bacterial inhibition, cell migration, and cell adhesion in an in vitro model. Additionally, no toxicity was observed in the fibroblasts and red blood cells. Therefore, given the above-mentioned advantages, this product can be a promising candidate for wound dressing applications.
Topics & Concepts
NiosomeSwellingWound healingChemistryPectinIn vivoDispersityParticle sizeSelf-healing hydrogelsCytotoxicityIrritationDrug carrierBiomedical engineeringIn vitroDrug deliveryMaterials scienceFood scienceSurgeryPolymer chemistryComposite materialBiochemistryMembraneMedicineOrganic chemistryVesicleImmunologyBiotechnologyBiologyPhysical chemistryWound Healing and TreatmentsPolysaccharides and Plant Cell WallsAdvancements in Transdermal Drug Delivery