The CD39-CD73-adenosine axis: Master regulator of immune evasion and therapeutic target in pancreatic ductal adenocarcinoma
Xiaolong Liu, Qingzhu Ding, Han Zhang, Xiang Zhang, Qiangda Chen, Shangeng Weng
Topics & Concepts
AdenosineCancer researchAdenosine receptorPurinergic receptorPurinergic signallingImmune systemStromal cellBiologyReceptorMedicineSignal transductionDownregulation and upregulationImmunologyCellPancreatic cancerMediatorImmune checkpointRegulatorImmunotherapyCell biologyAdenosine A1 receptorPharmacologyTumor microenvironmentDuctal cellsAdenosine and Purinergic SignalingAdolescent and Pediatric HealthcareImmune Cell Function and Interaction