Renal and hypothalamic inflammation in renovascular hypertension: role of afferent renal nerves
Mariana Ruiz Lauar, Louise Evans, Dusty Van Helden, Gregory D. Fink, Christopher T. Banek, José Vanderlei Menani, John W. Osborn
2023American Journal of Physiology-Regulatory, Integrative and Comparative Physiology21 citationsDOIOpen Access PDF
Abstract
Hypertension resulting from reduced perfusion of the kidney is dependent on renal sensory nerves, which are linked to inflammation in the kidney and hypothalamus. Afferent renal nerves are required for chronic increases in both water intake and vasopressin release observed following renal artery stenosis. Findings from this study suggest an important role of renal sensory nerves that has previously been underestimated in the pathogenesis of 2K1C hypertension.
Topics & Concepts
Renovascular hypertensionMedicineAfferentInflammationKidneyAfferent arteriolesInternal medicineUrologyCardiologyBlood pressureRenin–angiotensin systemSodium Intake and HealthCardiovascular, Neuropeptides, and Oxidative Stress ResearchBlood Pressure and Hypertension Studies