CD4<sup>+</sup> T cell exhaustion leads to adoptive transfer therapy failure which can be prevented by immune checkpoint blockade.
Jinfei Fu, Anze Yu, Xiang Xiao, Juyu Tang, Xiongbing Zu, Wenhao Chen, Bin He
Abstract
T lymphocytes.
Topics & Concepts
Cytotoxic T cellImmune checkpointImmune systemAdoptive cell transferImmunologyCD8BlockadeMelanomaCancer researchImmunityImmunotherapyAntigenT cellTumor-infiltrating lymphocytesMedicineBiologyReceptorInternal medicineIn vitroBiochemistryCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionImmunotherapy and Immune Responses