Chronic stress drives liver cancer by impairing the hepatic kynurenine pathway and immune surveillance
Renhui Sun, Deyan Jiao, Wenjing Yuan, Hao Wang, Lingtong Ren, Zhendong Fu, Jiaxuan Zhang, Xuetian Yue, Zhuanchang Wu, Chunyang Li, Huili Hu, M. Wang, Lifen Gao, Chunhong Ma, Xiaohong Liang
Topics & Concepts
Kynurenic acidQuinolinic acidKynurenineImmune systemKynurenine pathwayLiver cancerCancerChronic stressImmunologyEffectorMedicineCancer researchNicotinamideBiologyLiver cellCancer cellIndoleamine 2,3-dioxygenaseEndocrinologyOxidative stressLiver functionTryptophan MetabolismReceptorInternal medicineCellImmunityNicotinamide adenine dinucleotideImmune checkpointInflammationQuinolinateT cellNicotinamide adenine dinucleotide phosphateTryptophan and brain disordersCancer, Stress, Anesthesia, and Immune ResponseStress Responses and Cortisol