Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR–Cas9
Łukasz Nierzwicki, Kyle W. East, Jonas M. Binz, Rohaine V. Hsu, Mohd Ahsan, Pablo R. Arantes, Erin Skeens, Martin Pačesa, Martin Jínek, George P. Lisi, Giulia Palermo
Topics & Concepts
CRISPRCas9ChemistryDNACleavage (geology)NucleaseGenome editingMolecular dynamicsBiophysicsBiochemistryComputational chemistryBiologyGeneFracture (geology)PaleontologyCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesElectrocatalysts for Energy Conversion