Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
Rui Zhang, Heng Li, Xianglei Zhang, Jian Li, Haixia Su, Qiukai Lu, Guangyu Dong, Huixia Dou, Chen Fan, Zhanni Gu, Qianwen Mu, Wei Tang, Yechun Xu, Hong Liu
Topics & Concepts
ChemistryPsoriasisPharmacologyPhosphodiesteraseCyclic adenosine monophosphateIn vivoDrugRoflumilastPotencyEnzymeIn vitroBiochemistryInternal medicineMedicineImmunologyReceptorBiotechnologyCOPDBiologyMast cells and histaminePhosphodiesterase function and regulationAsthma and respiratory diseases