Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase
Rostom Ahmed‐Belkacem, Priscila Sutto‐Ortiz, Mathis Guiraud, Bruno Canard, Jean‐Jacques Vasseur, Étienne Decroly, Françoise Debart
Topics & Concepts
MethyltransferaseRNAMethylationEnzymeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)BiologyDocking (animal)ChemistryBiochemistryStereochemistryGuanineNucleotideDNAGeneInfectious disease (medical specialty)DiseaseNursingPathologyMedicineRNA modifications and cancerRNA and protein synthesis mechanismsCRISPR and Genetic Engineering