Pyrimidine-morpholine hybrids as potent druggable therapeutics for Alzheimer’s disease: Synthesis, biochemical and in silico analyses
Sumera Zaib, Muhammad Tayyab Younas, Imtiaz Khan, Hafiz Saqib Ali, C. John McAdam, Jonathan M. White, Fadi Jaber, Nasser S. Awwad, Hala A. Ibrahium
Topics & Concepts
MorpholineChemistryDruggabilityADMEPyrimidineTacrineStereochemistryIn silicoDrug discoveryDocking (animal)Drug designLead compoundCombinatorial chemistryBiochemistryEnzymeAcetylcholinesteraseIn vitroOrganic chemistryGeneMedicineNursingCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity