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Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis

Katharina Heinzelmann, Qianjiang Hu, Yan Hu, Evgenia Dobrinskikh, Meshal Ansari, M. Camila Melo-Narváez, Henrik M. Ulke, Colton Leavitt, Carol Mirita, Tammy Trudeau, Maxwell L. Saal, Pamela L. Rice, Bifeng Gao, William J. Janssen, Ivana V. Yang, Herbert B. Schiller, Eszter K. Vladar, Mareike Lehmann, Mélanie Königshoff

2022European Respiratory Journal57 citationsDOIOpen Access PDF

Abstract

<b>Bronchiolisation and honeycombing are features of IPF. ScRNA sequencing identified GPR87 as a novel marker of basal cells in IPF, enriched in honeycomb cysts. GPR87 overexpression resulted in aberrant airway cell differentiation.</b>https://bit.ly/3i4dXeT

Topics & Concepts

HoneycombingHoneycombMedicineBasal (medicine)CellIdiopathic pulmonary fibrosisPathologyRNAStem cell markerLungInternal medicineBiologyGeneGeneticsInsulinBotanyNeonatal Respiratory Health ResearchInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisCongenital Diaphragmatic Hernia Studies
Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis | Litcius