The PP2A regulatory subunit PPP2R2A controls NAD+ biosynthesis to regulate T cell subset differentiation in systemic autoimmunity
Wenliang Pan, Maria Tsokos, Marc Scherlinger, Wei Li, George C Tsokos
Abstract
through the NR-directed salvage pathway and promotes systemic autoimmunity. Translationally, NR suppresses lupus nephritis in mice and limits the production of proinflammatory cytokines by SLE T cells.
Topics & Concepts
AutoimmunityProtein phosphatase 2Protein subunitImmune systemCell biologyBiologyImmunologyNAD+ kinaseGeneticsBiochemistryGeneEnzymeAdenosine and Purinergic SignalingSystemic Lupus Erythematosus ResearchImmune Cell Function and Interaction