Untargeted metabolomics for uncovering plasma biological markers of wet age-related macular degeneration
Yanhui Deng, Ping Shuai, Haixin Wang, Shanshan Zhang, Jie Li, Mingyan Du, Peirong Huang, Chao Qu, Lulin Huang
Abstract
experiments. Among them, cyclamic acid reduced the activity, inhibited the proliferation, increased the apoptosis and necrosis in human retinal pigment epithelial cells (HRPECs). L-tryptophanamide affected the proliferation, apoptosis and necrosis in HRPECs, and promoted the tube formation and migration in primary human retinal endothelial cells (HRECs). Hyodeoxycholic acid and O-phosphorylethanolamine inhibited the tube formation and migration in HRECs. The results suggested that differential metabolites have certain effects on wAMD pathogenesis-related HRPECs and HRECs.
Topics & Concepts
Macular degenerationApoptosisChoroidal neovascularizationRetinalPathogenesisGenotypeNecrosisChemistryBiologyMolecular biologyBiochemistryMedicineImmunologyGeneticsOphthalmologyGeneRetinal Diseases and TreatmentsGlaucoma and retinal disordersRetinal Imaging and Analysis