Phytochemical Curcumin-Coformulated, Silver-Decorated Melanin-like Polydopamine/Mesoporous Silica Composites with Improved Antibacterial and Chemotherapeutic Effects against Drug-Resistant Cancer Cells
Yiyan Song, Ling Cai, Zhongcheng Tian, Yuan Wu, Jin Chen
Abstract
(24 h), attributing to the enhanced effect of the bactericide of silver nanoparticles and curcumin. Furthermore, through the utilization of the nanoformulation of curcumin, improved chemotherapeutic efficiency against human cervical cancer cells (HeLa) and Taxol-resistant nonsmall cell lung cells (A549/TAX) was identified in comparison with that of free curcumin. Thus, our study rationalized the combinational design of the natural compound and silver nanoparticles as an integrated dual-responsive nanoplatform in dealing with infectious bacteria and drug resistance in cancers for enhanced therapy.
Topics & Concepts
CurcuminMesoporous silicaBiocompatibilityNanocarriersChemistryHeLaSilver nanoparticleAntimicrobialPhytochemicalMaterials scienceMesoporous materialNanoparticleNanotechnologyCellOrganic chemistryBiochemistryCatalysisCurcumin's Biomedical ApplicationsPolydiacetylene-based materials and applicationsDendrimers and Hyperbranched Polymers