Fe-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and Grignard reagents
Lei Liu, Wes Lee, Cassandra R. Youshaw, Mingbin Yuan, Michael B. Geherty, Peter Y. Zavalij, Osvaldo Gutiérrez
Abstract
A highly selective iron-catalyzed three-component dicarbofunctionalization of unactivated alkenes with alkyl halides and sp <sup>2</sup> -hybridized Grignard reagents is reported.
Topics & Concepts
HalideAlkylReagentCatalysisChemistryComponent (thermodynamics)Grignard reagentOrganic chemistryMedicinal chemistryCombinatorial chemistryPhysicsThermodynamicsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis