The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation
Yu Zhong, Tong Huang, Jiewen Huang, Jieru Quan, Guomei Su, Zhilin Xiong, Yingying Lv, Shihai Li, Xianwen Lai, Yuanyuan Xiang, Qu Wang, Lianxiang Luo, Xiao Gao, Yi Ming Shao, Jing Tang, Tianwen Lai
Abstract
Our results revealed that HDAC10-STAT3 interaction governs macrophage polarization to promote airway inflammation in asthma, implicating HDAC10 as a therapeutic target.
Topics & Concepts
Macrophage polarizationHDAC10InflammationMacrophageImmunologyMedicineHistone deacetylaseCancer researchChemistryHistoneBiochemistryIn vitroGeneHistone Deacetylase Inhibitors ResearchCytokine Signaling Pathways and InteractionsEpigenetics and DNA Methylation