Visible-light-enabled multicomponent synthesis of trifluoromethylated 3-indolequinoxalin-2(1H)-ones without external photocatalysis
Letian Zhang, Kai Zheng, Pengfei Zhang, Min Jiang, Jiabin Shen, Chao Chen, Chao Shen
Abstract
A novel and sustainable visible-light-enabled multicomponent reaction involving quinoxalin-2(1H)-ones, indoles, and CF3SO2Na that does not require an external photocatalyst is described. This photoinduced reaction employs air as the sole oxidant, thereby providing a green and highly step-efficient approach to a series of biologically important trifluoromethylated 3-indolequinoxalin-2(1H)-ones.
Topics & Concepts
PhotocatalysisVisible spectrumChemistryNanotechnologyPhotochemistryCombinatorial chemistryMaterials scienceCatalysisOrganic chemistryOptoelectronicsSynthesis and Biological EvaluationFluorine in Organic ChemistryRadical Photochemical Reactions