Spt5 Phosphorylation and the Rtf1 Plus3 Domain Promote Rtf1 Function through Distinct Mechanisms
Jennifer J. Chen, Jean Mbogning, Mark A. Hancock, Dorsa Majdpour, Manan Madhok, Hassan Nassour, Juliana C.C. Dallagnol, Viviane Pagé, David Chatenet, Jason C. Tanny
Abstract
We further show that the C-terminal region of Prf1, which also interacts with PAF, has a similar parallel function with pSpt5. Our results elucidate unexpected complexity underlying Cdk9-dependent pathways that regulate transcription elongation.
Topics & Concepts
RNA polymerase IIBiologyElongation factorSchizosaccharomyces pombeSchizosaccharomycesCell biologyTranscription factorP-TEFbPhosphorylationMolecular biologyGeneticsRNASaccharomyces cerevisiaeYeastGeneRibosomeGene expressionPromoterRNA Research and SplicingGenomics and Chromatin DynamicsRNA modifications and cancer