Myocardium-targeted transplantation of PHD2 shRNA-modified bone mesenchymal stem cells through ultrasound-targeted microbubble destruction protects the heart from acute myocardial infarction
Zhenxing Sun, Yuji Xie, Robert J. Lee, Yihan Chen, Qiaofeng Jin, Qing Lv, Jing Wang, Yali Yang, Yuman Li, Yu Cai, Rui Wang, Zhengyang Han, Li Zhang, Mingxing Xie
Abstract
The delivery of PHD2 shRNA-modified BMSCs by UTMD promoted grafted cell homing and activity, and increased myocardial angiogenesis in the infarcted heart, leading to improved cardiac function. This combination may provide a promising strategy for enhancing the effectiveness of stem cell therapy after acute myocardial infarction.
Topics & Concepts
TransplantationSmall hairpin RNAMesenchymal stem cellAngiogenesisMedicineStem cellHoming (biology)Myocardial infarctionCancer researchApoptosisInternal medicineCell biologyChemistryPathologyBiologyGene knockdownEcologyBiochemistryUltrasound and Hyperthermia ApplicationsMesenchymal stem cell researchElectrospun Nanofibers in Biomedical Applications