Oxidative imbalance increases the risk for colonic polyp and colorectal cancer development
Dimitrios Tsounis, Vassiliki Villiotou, Angeliki Melpidou, Chara Pantsiou, Alexandra Argyrou, Charis Giannopoulou, Adriani Grigoratou, Dimitra Rontogianni, Gerassimos J. Mantzaris, George Papatheodoridis
Abstract
BACKGROUND: The role of oxidative stress in the pathogenesis of colorectal carcinoma (CRC) has garnered considerable interest recently. Specific oxidative factors have been implicated in the pathogenesis of adenomatous polyps and ultimately adenocarcinoma. AIM: To evaluate the effect of oxidative imbalance as quantified by specific serological markers in the development of sporadic colon adenocarcinoma. METHODS: ), and malondialdehyde and results were compared between groups. RESULTS: are associated with a higher risk, whereas lower levels of malondialdehyde with a lower risk. CONCLUSION: Increased oxidative stress may play an important role in the pathogenesis and progression of CRC. Antioxidants' presence may exert a protective effect in the very early stages of colon carcinogenesis.