Tunable hybrid carbon metabolism coordination for the carbon-efficient biosynthesis of 1,3-butanediol in<i>Escherichia coli</i>
Jian Wang, Ruihua Zhang, Jianli Zhang, Xinyu Gong, Tian Jiang, Xinxiao Sun, Xiaolin Shen, Jia Wang, Qipeng Yuan, Yajun Yan
Abstract
To achieve low-carbon bioeconomy, we established a carbon-efficient bioproduction approach by fine-tuning a non-glycolysis pathway, which reduces CO 2 emission and balances the acetyl-CoA and redox supply from sugar breakdown to pathway demand.
Topics & Concepts
BioproductionCarbon fibersChemistrySugarBiosynthesisMetabolic pathwayMetabolismEscherichia coliMetabolic engineeringBiochemistryRedoxOrganic chemistryMaterials scienceEnzymeGeneComposite numberComposite materialMicrobial Metabolic Engineering and BioproductionEnzyme Catalysis and ImmobilizationBiofuel production and bioconversion