Discovery of benzo[d]isothiazole derivatives as novel scaffold inhibitors targeting the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction through “ring fusion” strategy
Yinli Gao, Hanxun Wang, Lanlan Shen, Hanqing Xu, Minghui Deng, Maosheng Cheng, Jian Wang
Topics & Concepts
ChemistryStereochemistryJurkat cellsMoietyLigand (biochemistry)Programmed cell deathDocking (animal)BiochemistryT cellReceptorApoptosisNursingImmunologyImmune systemBiologyMedicineMonoclonal and Polyclonal Antibodies ResearchClick Chemistry and ApplicationsComputational Drug Discovery Methods