Sodium Fluoride Exposure Leads to ATP Depletion and Altered RNA Decay in Escherichia coli under Anaerobic Conditions
Oleg N. Murashko, Kun‐Hai Yeh, Chen-Hsin Albert Yu, Vladimir R. Kaberdin, Sue Lin‐Chao
Abstract
gene expression under anaerobic conditions. We reveal key gene clusters associated with cellular responses to fluoride and define its ATP-dependent stabilizing effects on transcripts containing repetitive extragenic palindromic sequences. We demonstrate the mechanisms controlling the RNA stability of these REP-containing mRNAs. Thus, fluoride can affect gene expression posttranscriptionally by stabilizing structured RNAs.
Topics & Concepts
TranscriptomeRNARNase PFluorideBiologyEscherichia coliGene expressionSodium fluorideDegradosomeGeneMessenger RNAAnaerobic exerciseChemistryMolecular biologyCell biologyBiochemistryInorganic chemistryPhysiologyBacterial Genetics and BiotechnologyRNA and protein synthesis mechanismsBiochemical and Molecular Research