DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and pyroptosis
Le Xin, Junhao Mu, Weiyan Peng, Jun Tang, Xiang Qin, Shaorong Tian, Yixiao Feng, Sanxiu He, Zhu Qiu, Guosheng Ren, Ailong Huang, Yong Lin, Qian Tao, Tingxiu Xiang
Abstract
Our study for the first time indicates ZDHHC1 is a potential tumor-suppressor frequently silenced due to promoter methylation, capable of negatively regulating metabolisms of tumor cells while stimulating oxidative stress and ER stress to expedite cell death through induction of pyroptosis and apoptosis, which can be exploited for development of new cancer prevention and therapies.
Topics & Concepts
DNA methylationBiologyEpigeneticsTXNIPMethylationCell growthCell biologyCancer researchCell cycleApoptosisMolecular biologyChemistryOxidative stressGene expressionBiochemistryGeneThioredoxinCancer, Hypoxia, and MetabolismEpigenetics and DNA MethylationRNA modifications and cancer