High confidence ATFS-1 target genes for quantifying activation of the mitochondrial unfolded protein response
Sonja K. Soo, Jeremy M. Van Raamsdonk
Abstract
were significantly upregulated under all three mitoUPR activating conditions. We ranked the 61 genes according to the magnitude of upregulation and identify multiple genes that may serve as robust readouts of mitoUPR activation.
Topics & Concepts
Unfolded protein responseGene knockdownDownregulation and upregulationRNA interferenceBiologyGeneCell biologyTranscription factorProteostasisMitochondrionGene silencingGene expressionRegulation of gene expressionGeneticsRNAMitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsAdipose Tissue and Metabolism