Covalent organic framework-engineered polydopamine nanoplatform for multimodal imaging-guided tumor photothermal-chemotherapy
Peng Gao, Ruyue Wei, Xiaohan Liu, Yuanyuan Chen, Tong Wu, Mingwan Shi, Mengzhen Wang, Na Li, Bo Tang
Abstract
A covalent organic framework (COF)-engineered polydopamine core-shell nanoplatform (PDA@COF) was developed. The ultrasmall pores and abundant functional sites of the COF endowed the nanoplatform with enhanced drug loading capacity and diminished drug leakage effect. Multimodal imaging-guided photothermal chemo-synergistic tumor-targeted therapy was realized after rational functionalization. This work offers new insights for developing COF-based multifunctional theranostic systems.
Topics & Concepts
Photothermal therapyCovalent bondNanotechnologyMaterials scienceChemistryBiomedical engineeringMedicineOrganic chemistryNanoplatforms for cancer theranosticsAdvanced Photocatalysis TechniquesCovalent Organic Framework Applications