Decreased cardio-respiratory information transfer is associated with deterioration and a poor prognosis in critically ill patients with sepsis
Cecilia Morandotti, Matthew Wikner, Qijun Li, Emily Ito, Tope Oyelade, Calix Tan, Pin‐Yu Chen, Anika Cawthorn, Watjana Lilaonitkul, Ali R. Mani
Abstract
This study adopts an integrative approach through physiological network analysis to investigate sepsis, with the goal of identifying differences in information transfer between physiological signals in sepsis survivors versus nonsurvivors. We found that greater information flow between heart rate, respiratory rate, and capillary oxygen saturation was associated with reduced mortality, independent of age, disease severity, and comorbidities. In addition, reduced information transfer was linked to an increased risk of 48-h deterioration in patients with sepsis.
Topics & Concepts
MedicineSepsisSOFA scoreRelative riskConfoundingCardiorespiratory fitnessHeart rateRespiratory rateProportional hazards modelSAPS IIInternal medicineIntensive care medicineAPACHE IIIntensive care unitBlood pressureConfidence intervalHeart Rate Variability and Autonomic ControlBlood Pressure and Hypertension StudiesSepsis Diagnosis and Treatment