Electrosprayed Eudragit RL100 nanoparticles with Janus polyvinylpyrrolidone patches for multiphase release of paracetamol
Jianfeng Zhou, Hao Pan, Wenjian Gong, Deng‐Guang Yu, Yuhao Sun
Abstract
animal experiments indicated that the Janus particles, on one hand, could provide a faster therapeutic effect than the electrosprayed sustained-release RL100 nanoparticles. On the other hand, they could maintain a therapeutic blood drug concentration for a longer period. The controlled release mechanism of the drug was proposed. The protocols reported here pioneer a new process-structure-performance relationship for developing Janus-structure-based advanced nano-DDSs.
Topics & Concepts
PolyvinylpyrrolidoneNanoparticleJanusMaterials scienceChemical engineeringChromatographyNanotechnologyChemistryPolymer chemistryEngineeringPickering emulsions and particle stabilizationElectrohydrodynamics and Fluid DynamicsInnovative Microfluidic and Catalytic Techniques Innovation