Lymph node–resident dendritic cells drive T <sub>H</sub> 2 cell development involving MARCH1
Carlos A. Castellanos, Xin Ren, Steven Lomeli Gonzalez, Hong Kun Li, Andrew Schroeder, Hong-Erh Liang, Brian J. Laidlaw, Donglei Hu, Angel C. Y. Mak, Celeste Eng, José Rodríguez‐Santana, Michael A. LeNoir, Qi Yan, Juan C. Celedón, Esteban G. Burchard, Scott S. Zamvil, Satoshi Ishido, Richard M. Locksley, Jason G. Cyster, Xiaozhu Huang, Jeoung‐Sook Shin
Abstract
2 cell development depends on ubiquitin-mediated clearance of antigen-presenting and costimulatory molecules by LN-resident DCs and consequent control of TCR signaling.
Topics & Concepts
Ubiquitin ligaseCD86Lymph nodeCell biologyDendritic cellAntigen-presenting cellT cellT-cell receptorUbiquitinBiologyImmunologyImmune systemChemistryGeneGeneticsImmunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Cell Function and Interaction