The Microenvironment’s Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications
Alessandro Pileri, Alba Guglielmo, Vieri Grandi, Silvia Alberti Violetti, Daniele Fanoni, Paolo Fava, Claudio Agostinelli, Emilio Berti, Pietro Quaglino, Nicola Pimpinelli
Abstract
BACKGROUND: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. METHODS: This paper aims to revise in a narrative way our current knowledge of the microenvironment's role in MF/SS. RESULTS AND CONCLUSIONS: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.
Topics & Concepts
Mycosis fungoidesMedicineTumor microenvironmentDermatologyCancer researchImmunologyLymphomaTumor cellsCutaneous lymphoproliferative disorders researchCAR-T cell therapy researchToxin Mechanisms and Immunotoxins