Nanomaterials as therapeutic agents to modulate astrocyte-mediated inflammation in spinal cord injury
Wenqi Luo, Yueying Li, Chunyu Xiang, Toshimi Aizawa, Renrui Niu, Yiming Wang, Jianhui Zhao, Zeping Liu, Chaoyuan Li, Wanguo Liu, Rui Gu
Abstract
Promoting the recovery of neurological function in patients with traumatic spinal cord injury (TSCI) remains challenging. The balance between astrocyte-mediated neurotrophic and pro-inflammatory responses is critical for TSCI repair. Recently, the utilization of nanomaterials has been considerably explored in immunological reconstructive techniques that specifically target astrocyte-mediated inflammation, yielding positive outcomes. In this review, we aim to condense the present knowledge regarding the astrocyte-mediated inflammation following TSCI. We then review the various categories of nanomaterials utilized in the management of astrocyte-mediated inflammation in TSCI and conclude by summarizing their functions and advantages to offer novel insights for the advancement of effective clinical strategies targeting TSCI.