USP14 modulates stem-like properties, tumorigenicity, and radiotherapy resistance in glioblastoma stem cells through stabilization of MST4-phosphorylated ALKBH5
Xiao Zhou, Qiaoxi Xia, Botao Wang, Junjun Li, Bing Liu, Sisi Wang, Min Huang, Ronghui Zhong, Shi‐Yuan Cheng, Xuan Wang, Xiaobing Jiang, Tianzhi Huang
Abstract
Our results identify the MST4-USP14-ALKBH5 signaling pathway as a promising therapeutic target for treating GBM.
Topics & Concepts
GlioblastomaStem cellCancer researchPhosphorylationCancer stem cellChemistryBiologyCell biologyCancer, Hypoxia, and MetabolismRNA modifications and cancerRadiation Therapy and Dosimetry