Discovery of new benzhydrol biscarbonate esters as potent and selective apoptosis inducers of human melanomas bearing the activated ERK pathway: SAR studies on an ERK MAPK signaling modulator, ACA-28
Ryosuke Satoh, Naoya Hamada, A Yamada, Yuki Kanda, Fumihiro Ishikawa, Teruaki Takasaki, Genzoh Tanabe, Reiko Sugiura
Topics & Concepts
ChemistryMAPK/ERK pathwayApoptosisBearing (navigation)InducerSignal transductionCell biologyCancer researchBiochemistryGeneBiologyGeographyCartographyComputational Drug Discovery MethodsMelanoma and MAPK PathwaysSynthesis and biological activity