LDCMFC: Predicting Long Non-Coding RNA and Disease Association Using Collaborative Matrix Factorization Based on Correntropy
Wenyu Xi, Feng Zhou, Ying-Lian Gao, Jin‐Xing Liu, Chun-Hou Zheng
Abstract
With the development of bioinformatics, the important role played by lncRNAs in various intractable diseases has aroused the interest of many experts. In recent studies, researchers have found that several human diseases are related to lncRANs. Moreover, it is very difficult and expensive to explore the unknown lncRNA-disease associations (LDAs), so only a few associations have been confirmed. It is vital to find a more accurate and effective method to identify potential LDAs. In this study, a method of collaborative matrix factorization based on correntropy (LDCMFC) is proposed for the identification of potential LDAs. To improve the robustness of the algorithm, the traditional minimization of the Euclidean distance is replaced with the maximized correntropy. In addition, the weighted K nearest known neighbor (WKNKN) method is used to rebuild the adjacency matrix. Finally, the performance of LDCMFC is tested by 5-fold cross-validation. Compared with other traditional methods, LDACMFC obtains a higher AUC of 0.8628. In different types of studies of three important cancer cases, most of the potentially relevant lncRNAs derived from the experiments have been validated in the databases. The final result shows that LDCMFC is a feasible method to predict LDAs.