Two novel chiral tetranucleate copper-based complexes: syntheses, crystal structures, inhibition of angiogenesis and the growth of human breast cancer<i>in vitro</i>and<i>in vivo</i>
Xiaoxiao Hou, Yaping Ren, Zhaohui Luo, Bingli Jiang, Tiantian Lu, Fu‐Ping Huang, Xiu‐Ying Qin
Abstract
TNCu-A can remarkably inhibit the growth of triple-negative breast cancer from which MDA-MB-231 cells were xenografted into severely immunodeficient nude mice by inhibiting proliferation, inducing apoptosis of MDA-MB-231 cells by dramatically inhibiting the expression of the anti-apoptotic protein Bcl-2 and up-regulating the expressions of proapoptotic proteins caspase-9 and Bax, and simultaneously inhibiting tumor angiogenesis by decreasing the density of vascular endothelial cells and suppressing migration and even partially inducing apoptosis.
Topics & Concepts
In vivoIn vitroHuman breastCopperAngiogenesisChemistryBreast cancerStereochemistryGrowth inhibitionCancer researchBiochemistryCancerBiologyOrganic chemistryGeneticsMetal complexes synthesis and propertiesCrystal structures of chemical compoundsMetal-Organic Frameworks: Synthesis and Applications