Co-delivery of proanthocyanidin and mitoxantrone induces synergistic immunogenic cell death to potentiate cancer immunotherapy
Ying Qian, Jiarong Mao, Xuejiao Leng, Ling Zhu, Rui Xue, Zhetong Jin, Houzhe Jiang, Heng Liu, Fengguang Zhang, Xiaolin Bi, Zhipeng Chen, Jingjing Wang
Abstract
synergistically triggers higher ICD with the release of the high mobility group box-1 (HMGB-1) and calreticulin (CRT). After intravenous injection of DMP@NPs, the local tumor microenvironment of CT26 tumor-bearing mice was reprogrammed, and dendritic cell activation and T cell infiltration were significantly increased. Most importantly, the synergistic immune nanodrug DMP@NPs improved the efficacy of colorectal cancer immunotherapy and reduced toxicity and side effects for the immune organs.
Topics & Concepts
Immunogenic cell deathMitoxantroneImmunotherapyCancer immunotherapyChemistryCancer researchProgrammed cell deathProanthocyanidinCancerPharmacologyApoptosisMedicineChemotherapyBiochemistryPolyphenolInternal medicineAntioxidantImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryImmune Cell Function and Interaction