Cooling-Triggered Release from Mesoporous Poly(<i>N</i>-isopropylacrylamide) Microgels at Physiological Conditions
Anna S. Vikulina, Natalia A. Feoktistova, Н. Г. Балабушевич, Regine von Klitzing, Dmitry Volodkin
Abstract
microcrystals. In addition, the fabrication of hollow thermoresponsive pNIPAM microshells has been demonstrated, utilizing vaterite microcrystals that had narrower pores. The proposed approach for heating-triggered encapsulation and cooling-triggered release into/from pNIPAM microgels may pave the ways for applications of pNIPAM hydrogels for skin and transdermal cooling-responsive drug delivery in the future.
Topics & Concepts
Materials scienceSelf-healing hydrogelsPoly(N-isopropylacrylamide)Chemical engineeringDrug deliveryTransdermalMesoporous materialDextranCopolymerNanoscopic scaleNanotechnologyFabricationPolymer chemistryPolymerComposite materialChemistryCatalysisOrganic chemistryPharmacologyMedicineAlternative medicineEngineeringPathologyHydrogels: synthesis, properties, applications3D Printing in Biomedical ResearchAdvanced Materials and Mechanics