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Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS

Rong Wu, Yingzhi Ye, Daoyuan Dong, Zhe Zhang, Shaopeng Wang, Yini Li, Noelle Wright, Javier Redding‐Ochoa, Koping Chang, Shaohai Xu, Xueting Tu, Chengzhang Zhu, Lyle W. Ostrow, Xavier Roca, Juan C. Troncoso, Bin Wu, Shuying Sun

2024Neuron32 citationsDOIOpen Access PDF

Topics & Concepts

C9orf72Frontotemporal dementiaTrinucleotide repeat expansionRNA splicingAmyotrophic lateral sclerosisRNAExonIntronBiologyStress granuleNeurodegenerationCell biologyTranslation (biology)Messenger RNAPathologyMedicineGeneticsGeneDementiaDiseaseAlleleAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchRNA Research and Splicing
Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS | Litcius