TCRα reporter mice reveal contribution of dual TCRα expression to T cell repertoire and function
Letitia Yang, Burhan Jama, Huawei Wang, Lara Labarta-Bajo, Elina I. Zúñiga, Gerald P. Morris
Abstract
Significance This study utilizes novel transgenic reporter mice to definitively evaluate T cells coexpressing two T cell antigen receptors. These experiments demonstrate that T lymphocytes naturally coexpressing two different antigen receptors are significantly more abundant than previous estimates and that these cells have a previously unappreciated role in physiologic immune responses.
Topics & Concepts
T-cell receptorRepertoireFunction (biology)T cellDual (grammatical number)Cell biologyBiologyMolecular biologyImmunologyImmune systemArtLiteratureT-cell and B-cell ImmunologyCAR-T cell therapy researchImmune Cell Function and Interaction