The <i>In Vitro</i> Replication Cycle of Achromobacter xylosoxidans and Identification of Virulence Genes Associated with Cytotoxicity in Macrophages
Adam M. Pickrum, Molly O. Riegert, Clive Wells, Kenneth L. Brockman, Dara W. Frank
Abstract
Patients affected by CF develop chronic bacterial infections characterized by inflammatory exacerbations and tissue damage. Advancements in sequencing technologies have broadened the list of opportunistic pathogens colonizing the CF lung. A. xylosoxidans is increasingly recognized as an opportunistic pathogen in CF, yet our understanding of the bacterium as a contributor to human disease is limited.
Topics & Concepts
Achromobacter xylosoxidansVirulenceCytotoxicityBiologyMicrobiologyIdentification (biology)Replication (statistics)In vitroGeneAchromobacterGeneticsBacteriaVirologyPseudomonasEcologyInfections and bacterial resistanceCancer Research and TreatmentsMicrobial metabolism and enzyme function