Dinuclear zinc-catalyzed asymmetric Friedel–Crafts alkylation/cyclization of 3-aminophenols with α,α-dicyanoolefins
Hang Yan, Shi‐Kun Jia, Yu‐Huan Geng, Jiaojiao Han, Yuan‐Zhao Hua, Min‐Can Wang
Abstract
This is the first asymmetric example of the dinuclear zinc-catalysed functionalization of aromatic C(sp 2 )–H bonds.
Topics & Concepts
Friedel–Crafts reactionCatalysisAlkylationChemistryZincMedicinal chemistryOrganic chemistryCombinatorial chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis of Indole Derivatives