The Epstein-Barr Virus Glycoprotein BDLF2 Is Essential for Efficient Viral Spread in Stratified Epithelium
Joshua J. Walston, Ian R. Hayman, Mindy Gore, Mary Ferguson, Rachel M. Temple, Jason Liao, Samina Alam, Craig Meyers, Sharof M. Tugizov, Lindsey Hutt‐Fletcher, Clare E. Sample
Abstract
, we have ascertained that the loss of the viral envelope protein BDLF2 had little effect on the EBV life cycle in B cells but severely restricted the number of infected cells in organotypic cultures. Loss of BDLF2 has a substantial impact on the size of infected areas, suggesting that BDLF2 plays a specific role in the spread of infection in stratified epithelium.
Topics & Concepts
BiologyVirologyEpstein–Barr virusEpitheliumVirusGlycoproteinViral life cycleGammaherpesvirinaeSalivaHerpesviridaeImmunologyViral replicationViral diseaseMolecular biologyGeneticsBiochemistryViral-associated cancers and disordersLymphoma Diagnosis and TreatmentHistiocytic Disorders and Treatments