Comprehensive phenotyping of human peripheral blood B lymphocytes in pathological conditions
Rita Carsetti, Francesco Corrente, Claudia Capponi, Mattia Mirabella, Simona Cascioli, Patrizia Palomba, Valentina Bertaina, Daria Pagliara, Manuela Colucci, Eva Piano Mortari
Abstract
Several diseases are associated with alterations of the B-cell compartment. Knowing how to correctly identify by flow cytometry the distribution of B-cell populations in the peripheral blood is important to help in the early diagnosis. In the accompanying article we describe how to identify the different B-cell subsets in the peripheral blood of healthy donors. Here we show a few examples of diseases that cause dysregulation of the B-cell compartment.
Topics & Concepts
Peripheral bloodFlow cytometryCompartment (ship)PeripheralMass cytometryPathologicalCellB cellBlood cellImmunologyMedicinePathologyBiologyPhenotypeInternal medicineGeneticsAntibodyGeologyOceanographyGeneImmunodeficiency and Autoimmune DisordersChronic Lymphocytic Leukemia ResearchBlood groups and transfusion