PNPase and RhlB Interact and Reduce the Cellular Availability of Oxidized RNA in <i>Deinococcus radiodurans</i>
Runhua Han, Jessie Jiang, Jaden Fang, Lydia M. Contreras
Abstract
Oxidative RNA damage can be caused by oxidative stress, such as hydrogen peroxide, ionizing radiation, and antibiotic treatment. 8-oxo-7,8-dihydroguanine (8-oxoG), a major type of oxidized RNA, is highly mutagenic and participates in a variety of disease occurrences and development. Although several proteins have been identified to recognize 8-oxoG-modified RNA, the knowledge of how RNA oxidative damage is controlled largely remains unclear, especially in nonmodel organisms.
Topics & Concepts
RNAPolynucleotide phosphorylaseBiologyCold-shock domainRNA-binding proteinDeinococcus radioduransRNA Helicase ADNAPurine nucleoside phosphorylaseMolecular biologyHelicaseBiochemistryGeneEnzymePurineRNA modifications and cancerRNA Research and SplicingRNA and protein synthesis mechanisms