ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes
Mengjun Ma, Hongyu Li, Peng Wang, Wen Yang, Rujia Mi, Jiahao Zhuang, Yuhang Jiang, Yixuan Lu, Xin Shen, Yanfeng Wu, Huiyong Shen
Abstract
. ATF6 may aggravate angiogenesis-osteogenesis coupling during AS by mediating FGF2 transcription in chondrocytes, implying that ATF6 represents a promising therapeutic target for AS.
Topics & Concepts
Ankylosing spondylitisAngiogenesisMedicineCell biologyImmunologyChemistryCancer researchBiologySpondyloarthritis Studies and TreatmentsInflammasome and immune disordersConnective tissue disorders research