Cobalt-Catalyzed<i>E</i>-Selective Isomerization of Alkenes with a Phosphine-Amido-Oxazoline Ligand
Hongmei Liu, Cheng Cai, Yanghao Ding, Jianhui Chen, Bosheng Liu, Yuanzhi Xia
Abstract
)-internal alkenes with benzylic selectivity. This protocol is atom-economy and operationally simple and uses readily available starting materials with good functional tolerance. This catalytic system could be scaled up to gram scale smoothly with a catalyst loading of 0.1 mol %.
Topics & Concepts
IsomerizationPhosphineCatalysisOxazolineChemistryLigand (biochemistry)CobaltCombinatorial chemistrySelectivityAtom economyMedicinal chemistryOrganic chemistryBiochemistryReceptorSynthetic Organic Chemistry MethodsCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis