PET ligands [ <sup>18</sup> F]LSN3316612 and [ <sup>11</sup> C]LSN3316612 quantify <i>O</i> -linked-β- <i>N</i> -acetyl-glucosamine hydrolase in the brain
Shuiyu Lu, Mohammad B. Haskali, Kevin M. Ruley, Nicolas Dreyfus, Susan L. DuBois, Soumen Paul, Jeih‐San Liow, Cheryl L. Morse, Aneta Kowalski, Robert L. Gladding, Jeremy Gilmore, Adrian J. Mogg, Stéphanie Morin, Peter J. Lindsay‐Scott, J. Craig Ruble, Nancy Kant, Sergey Shcherbinin, Vanessa Barth, Michael P. Johnson, María José Cuadrado, Enrique Jambrina, Andrew J. Mannes, Hugh Nuthall, Sami S. Zoghbi, Cynthia D. Jesudason, Robert B. Innis, Victor W. Pike
Abstract
C]LSN3316612 for future human studies, whereas either may be an effective positron emission tomography radioligand for quantifying brain OGA in rodent and monkey.
Topics & Concepts
ChemistryGlucosamineHydrolaseStereochemistryEnzymeBiochemistryGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisUbiquitin and proteasome pathways